منابع مشابه
Numerical Taxonomy of Birth Defects and Polygenic Disorders
This volume contains papers presented at a conference held at the Jackson Laboratory in 1976 under the auspices of the National Foundation. The papers deal with several extremely interesting observations and ideas that support the notion that senescence is genetically controlled. Even if the reader has not been previously acquainted with the literature on aging, this book will provide a readabl...
متن کاملAssociations between Polygenic Risk for Psychiatric Disorders and Substance Involvement
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 non-Hispani...
متن کاملShared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, an...
متن کاملAntioxidants: New-generation therapeutic base for treatment of polygenic disorders
Hyperphysiological burden of free radicals causes imbalance in homeostatic phenomena between oxidants and antioxidants in the body. This imbalance leads to oxidative stress that is being suggested as the root cause of aging and various human diseases like atherosclerosis, stroke, diabetes, cancer and neurodegenerative diseases such as Alzheimer’s disease and Parkinsonism. Therefore, in modern W...
متن کاملBrief Review: Increasing the Variance for Genes in RDS and Other Polygenic Disorders
I present two alternatives to simple gene frequency in testing for the potential association between different genes and polygenic traits. These are testing for molecular heterosis and testing for hidden variables such as the mother’s age at the birth of her first child. They have the potential to identify genes that may have appeared to be unassociated with the phenotype and to increase the pe...
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ژورنال
عنوان ژورنال: ABI Genetika
سال: 2007
ISSN: 0534-0012,1820-6069
DOI: 10.2298/gensr0702283p